Next available departures

Next departures for Rome to Isernia on August 14
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
		2:50pm	Rome Tiburtina Bus Station	2h 25m	5:15pm	Isernia	CheapestFastest
		10:25am	Rome Fiumicino Airport	7h 49m	6:14pm	Isernia	No tags

Next departures for Rome to Isernia on August 15
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
2:50pm	Rome Tiburtina Bus Station	2h 25m	5:15pm	Isernia	CheapestFastest
4:40am	Rome Fiumicino Airport	6h 54m	11:34am	Isernia	No tags
10:25am	Rome Fiumicino Airport	7h 49m	6:14pm	Isernia	No tags
5:15am	Aeroporto Ciampino Airport (CIA)	6h 19m	11:34am	Isernia	No tags

Next departures for Rome to Isernia on August 16
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
9:07am	Termini	2h 8m	11:15am	Isernia	CheapestFastest
5:40pm	Termini	2h 15m	7:55pm	Isernia	No tags
4:40am	Rome Fiumicino Airport	6h 54m	11:34am	Isernia	No tags
10:25am	Rome Fiumicino Airport	7h 49m	6:14pm	Isernia	No tags
5:15am	Aeroporto Ciampino Airport (CIA)	6h 19m	11:34am	Isernia	No tags
2:50pm	Rome Tiburtina Bus Station	2h 25m	5:15pm	Isernia	No tags

Next departures for Rome to Isernia on August 17
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
2:50pm	Rome Tiburtina Bus Station	2h 25m	5:15pm	Isernia	CheapestFastest
4:40am	Rome Fiumicino Airport	6h 54m	11:34am	Isernia	No tags
10:25am	Rome Fiumicino Airport	7h 49m	6:14pm	Isernia	No tags
5:15am	Aeroporto Ciampino Airport (CIA)	6h 19m	11:34am	Isernia	No tags

Next departures for Rome to Isernia on August 18
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
2:50pm	Rome Tiburtina Bus Station	2h 25m	5:15pm	Isernia	CheapestFastest
4:40am	Rome Fiumicino Airport	6h 54m	11:34am	Isernia	No tags
10:25am	Rome Fiumicino Airport	7h 49m	6:14pm	Isernia	No tags
5:15am	Aeroporto Ciampino Airport (CIA)	6h 19m	11:34am	Isernia	No tags

Next departures for Rome to Isernia on August 19
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
2:50pm	Rome Tiburtina Bus Station	2h 25m	5:15pm	Isernia	CheapestFastest
4:40am	Rome Fiumicino Airport	6h 54m	11:34am	Isernia	No tags
10:25am	Rome Fiumicino Airport	7h 49m	6:14pm	Isernia	No tags
5:15am	Aeroporto Ciampino Airport (CIA)	6h 19m	11:34am	Isernia	No tags

Next departures for Rome to Isernia on August 20
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
2:50pm	Rome Tiburtina Bus Station	2h 25m	5:15pm	Isernia	CheapestFastest
4:40am	Rome Fiumicino Airport	6h 54m	11:34am	Isernia	No tags
10:25am	Rome Fiumicino Airport	7h 49m	6:14pm	Isernia	No tags
5:15am	Aeroporto Ciampino Airport (CIA)	6h 19m	11:34am	Isernia	No tags

Last refresh of the prices: Today at 7:58 AM CEST.

Compare 2 ways to go from Rome to Isernia

We recommend taking the train

Among the sustainable travel choices, the Train stands out as a good way to reach Isernia. The journey takes about 2 hours 18 minutes, and with fares starting at just PLN 69, it presents an excellent value for a comfortable ride.

2train per day

2h 18mAverage Duration

148 kmDistance

4kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average PricePLN 59 - PLN 324	Average Duration6h 54m	CO₂ emissions 4kg CO₂e
Train	Average PricePLN 69 - PLN 112	Average Duration2h 18m	CO₂ emissions 4kg CO₂e

Bus stations and stops in Rome and Isernia

Stops in Rome

A
Termini
Piazza dei Cinquecento 1, 00185 Roma RM, Italy
Visit page
B
Rome Tiburtina Bus Station
Largo Guido Mazzoni, 3, 00162 Roma, Italy
Visit page
C
Rome Fiumicino Airport (FCO), Train station
Fiumicino Aeroporto, 00054 Fiumicino RM, Italy
Visit page
D
Roma S. Pietro
Roma S.Pietro, 00165 Roma RM, Italy
Visit page
E
Rome Ciampino Airport
Visit page
F
Roma Trastevere
Roma Trastevere Railway Station, 00152 Roma RM, Italy
Visit page

Stops in Isernia

A
Isernia
Piazza della Repubblica, 9, 86170 Isernia IS, Italy
Visit page

Compare companies

FlixBus

3.5/515,140 reviews

Staff4.1

Timeliness4.0

Cleanliness4.1

Wi‑Fi2.7

Trenitalia

3.9/569 reviews

Staff4.5

Timeliness4.4

Cleanliness4.7

Wi‑Fi2.7

Companies in IT:FlixBus, Trenitalia, BlaBlaCar Bus, Deutsche Bahn, ALSA, FlixTrain, Rede Expressos, RegioJet, Trenitalia, Deutsche Bahn ICE, Sindbad, NS Nederlandse Spoorwegen, MarinoBus, Italo

Frequently asked questions about travelling from Rome to Isernia by bus or train

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is a ticket from Rome to Isernia?
The cheapest tickets from Rome to Isernia start at PLN 59. The average price for this route is around PLN 127. Busbud recommends booking your tickets in advance for a better chance of getting the lowest possible price.
How long is the ride from Rome to Isernia?
The average trip duration from Rome to Isernia is 4h 36m, covering a distance of 152 km. The quickest vehicle can get you there in 2h 5m and is operated by Trenitalia.
Which companies service the Rome to Isernia route?
Several major companies operate on this route with 3 trips available per day, including services from FlixBus, Trenitalia.
What is the earliest and latest departure time from Rome to Isernia?
The earliest trip from Rome to Isernia departs at 4:05am. And the latest trip departs at 8:07pm.
What are the CO₂ emissions for the trip from Rome to Isernia?
A trip from Rome to Isernia generates an estimated 3.7813000000000003 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Which is the best company from Rome to Isernia?
According to Busbud customers, the highest-rated company on this route is Trenitalia, with an average rating of 3.9 out of 5 stars based on 69 reviews.
Which company has the best Wi-Fi from Rome to Isernia?
Based on Busbud reviews, the company FlixBus has the highest Wi‑Fi rating with a score of 2.7.
Which company has the most on-time service from Rome to Isernia?
According to Busbud traveller reviews, the most punctual company on this route is Trenitalia, with a punctuality rating of 4.4 out of 5 stars.
Which company has the cleanest vehicles from Rome to Isernia?
According to Busbud traveller reviews, the company with the cleanest vehicles on this route is Trenitalia, with a cleanliness rating of 4.7 out of 5 stars.

Find the cheapest prices for buses and trains

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

08-12

PLN 109

08-13

PLN 68

Today

PLN 91

08-15

PLN 71

08-16

PLN 65

08-17

PLN 70

08-18

PLN 64

08-19

PLN 61

The cheapest trip from Rome to Isernia was searched and found on Aug 19, 2026 with a price of PLN 61

To save money and make sure you have the best seat, it's a good idea to buy your bus and train tickets from Rome to Isernia, as early as possible.

You can expect to pay between PLN 61 and PLN 335 for a bus or train ticket from Rome to Isernia based on the past 2 days. You can expect to find the lowest price for this trip at PLN 61 on 2026-08-19.

Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.