Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Bus station | Indianapolis Bus Station | CheapestFastest | ||||
| Bus | Bus station | Indianapolis Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Bus station | Indianapolis Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Bus station | Downtown Transit Center | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Bus station | Downtown Transit Center | No tags |
Last refresh of the prices: Yesterday at 5:09 PM EDT.
Compare 2 ways to go from Florence to Indianapolis
Among the sustainable travel choices, the Bus stands out as a good way to reach Indianapolis. The journey takes about 23 hours and with fares starting at just $93, it presents an excellent value for a comfortable ride.
Where are the popular stops in Florence and Indianapolis?
Stops in Florence
- A619 S Irby St, Florence, SC 29501, USA
- B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
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Frequently asked questions about traveling from Florence, SC, US to Indianapolis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Florence to Indianapolis?
The cheapest bus tickets from Florence to Indianapolis start from $93. The average price for this route is around $100. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Florence to Indianapolis?
The average bus trip duration from Florence to Indianapolis is 23h, covering a distance of 521 miles (841 km). The quickest bus can get you there in 19h 55m and is operated by Greyhound.
Which bus companies service the Florence to Indianapolis route?
What is the earliest and latest departure time for the bus from Florence to Indianapolis?
The earliest bus departs from Florence to Indianapolis at 12:05am. And the latest bus departs at 4:30pm.
What are the CO₂ emissions for the bus trip from Florence to Indianapolis?
A bus trip from Florence to Indianapolis generates an estimated 21.003899999999998 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Florence to Indianapolis?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87531 reviews.
Which bus company has the best Wi-Fi from Florence to Indianapolis?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Florence to Indianapolis?
According to Busbud traveler reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Florence to Indianapolis?
According to Busbud traveler reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Florence, SC, US to Indianapolis was searched and found on Apr 8, 2026 with a price of $89To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Indianapolis, as early as possible.
You can expect to pay from $89 to $90 for a bus ticket from Florence, SC, US to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $89 which is on 2026-04-08.
What's the cheapest way to go from Florence, SC, US to Indianapolis?
The Bus is the cheapest travel choice for this destination
