Next departures for Prague to Brussels on August 22
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Prague (Central Bus Station Florenc)
Brussels South (Gare du Midi)
Cheapest
Bus
Prague (Central Bus Station Florenc)
Brussels North Train Station
Fastest
Bus
Prague (Central Bus Station Florenc)
Brussels Airport BRU (Parking P14)
No tags
Bus
Prague (Central Bus Station Florenc)
Brussels Airport BRU (Parking P14)
No tags
Bus
Prague (Central Bus Station Florenc)
Brussels Airport BRU (Parking P14)
No tags
Bus
Prague (Central Bus Station Florenc)
Brussels Airport BRU (Parking P14)
No tags
Bus
Prague (Main Railway Station)
Brussels Airport BRU (Parking P14)
No tags
Bus
Prague (Main Railway Station)
Brussels Airport BRU (Parking P14)
No tags
Next departures for Prague to Brussels on August 23
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Florenc
Brussels-South (Gare du Midi)
CheapestFastest
Next departures for Prague to Brussels on August 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
PRG Airport
Brussels North Train Station
Cheapest
Bus
Prague (Central Bus Station Florenc)
Brussels North Train Station
Fastest
Bus
Prague (Central Bus Station Florenc)
Brussels Airport BRU (Parking P14)
No tags
Bus
Prague (Central Bus Station Florenc)
Brussels Airport BRU (Parking P14)
No tags
Bus
Prague (Central Bus Station Florenc)
Brussels Airport BRU (Parking P14)
No tags
Bus
Prague (Main Railway Station)
Brussels Airport BRU (Parking P14)
No tags
Bus
Prague (Main Railway Station)
Brussels Airport BRU (Parking P14)
No tags
Bus
Prague (Main Railway Station)
Brussels Airport BRU (Parking P14)
No tags
Next departures for Prague to Brussels on August 25
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Florenc
Brussels South (Gare du Midi)
CheapestFastest
Last refresh of the prices: Yesterday at 12:17 PM CEST.
Compare 2 ways to go from Prague to Brussels
We recommend taking the bus
Among the sustainable travel choices, the Bus stands out as a good way to reach Brussels. The journey takes about 17 hours 55 minutes and with fares starting at just MAD 422, it presents an excellent value for a comfortable ride.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Based on 1103 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the departure location and the ticket access but often complained with the wifi. RegioJet ticket prices on this trip start at MAD 422
Based on 12666 reviews, the company was rated 3.7 stars on Busbud. Travelers were especially satisfied with the ticket access and the temperature but often complained with the wifi. BlaBlaCar Bus ticket prices on this trip start at MAD 675
Frequently asked questions about traveling from Prague to Brussels by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Prague to Brussels?
The cheapest bus tickets from Prague to Brussels start from MAD 422. The average price for this route is around MAD 921. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Prague to Brussels?
The average bus trip duration from Prague to Brussels is 17h 55m, covering a distance of 442 miles (713 km). The quickest bus can get you there in 12h and is operated by RegioJet.
Which bus companies service the Prague to Brussels route?
Several major bus companies operate on this route with 37 buses available per day, including services from FlixBus, RegioJet, BlaBlaCar Bus.
What is the earliest and latest departure time for the bus from Prague to Brussels?
The earliest bus departs from Prague to Brussels at 12:10am. And the latest bus departs at 11:50pm.
What are the CO₂ emissions for the bus trip from Prague to Brussels?
A bus trip from Prague to Brussels generates an estimated 17.817 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Prague to Brussels?
According to Busbud customers, the highest-rated bus company on this route is RegioJet, with an average rating of 4.1 out of 5 stars based on 1103 reviews.
Which bus company has the best Wi-Fi from Prague to Brussels?
Based on reviews on Busbud, the bus company RegioJet has the best Wi-Fi rating with a score of 3.8.
Which bus company has the most timely service from Prague to Brussels?
According to Busbud traveler reviews, the most timely bus company on this route is RegioJet, with a punctuality rating of 4.1 out of 5 stars.
Which bus company has the cleanest buses from Prague to Brussels?
According to Busbud traveler reviews, the bus company with the cleanest buses on this route is RegioJet, with a cleanliness rating of 4.4 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
08/20
MAD 760
08/21
MAD 863
Today
MAD 864
08/23
MAD 1,316
08/24
MAD 641
08/25
MAD 681
08/26
MAD 557
08/27
MAD 922
The cheapest trip from Prague to Brussels was searched and found on Aug 26, 2026 with a price of MAD 557
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Prague to Brussels, as early as possible.
You can expect to pay from MAD 557 to MAD 1,764 for a bus ticket from Prague to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at MAD 557 which is on 2026-08-26.
The cheapest trip from Prague to Brussels was searched and found on Aug 26, 2026 with a price of MAD 557
