Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Key West Bus Station | Downtown Transit Center | Cheapest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Key West Bus Station | Indianapolis Bus Station | Fastest | ||||
 | Bus | Key West Bus Station | Indianapolis Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Key West Bus Station | Downtown Transit Center | No tags |
Last refresh of the prices: 04/25/2026 EDT.
Get from Key West to Indianapolis
The journey takes about 1 day, 11 hours 25 minutes, and with fares starting at just R 2 983, it presents an excellent value for a comfortable ride.
Where are the popular stops in Key West and Indianapolis?
Stops in Key West
- A908 Caroline St, Key West, FL 33040, USA
- B
EYW Airport
3535 Florida A1A, Key West, FL 33040, USA
Compare bus companies
Based on 87546 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained about the Wi-Fi. Greyhound ticket prices on this trip start at R 3 180
Frequently asked questions about travelling from Key West to Indianapolis by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Key West to Indianapolis?
The cheapest bus tickets from Key West to Indianapolis start at R 2 983. The average price for this route is around R 3 754. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Key West to Indianapolis?
The average bus journey time from Key West to Indianapolis is 1d 11h, covering a distance of 1741 km. The fastest bus gets you there in 1d 11h and is operated by Greyhound.
Which bus companies service the Key West to Indianapolis route?
Several major bus companies operate on this route with 4 buses available per day.
What is the earliest and latest departure time for the bus from Key West to Indianapolis?
The earliest bus departs from Key West to Indianapolis at 10:00. And the latest bus departs at 17:00.
What are the CO₂ emissions for the bus trip from Key West to Indianapolis?
A bus trip from Key West to Indianapolis produces an estimated 43.520825 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Key West to Indianapolis was searched and found on 02 May 2026 with a price of R 3 109To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Key West to Indianapolis as early as possible.
You can expect to pay from R 3 109 to R 3 863 for a bus ticket from Key West to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at R 3 863, which is on 2026-05-03.
